Scientific Name: Macaca fascicularis
Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Euarchontoglires-> Primates-> Haplorrhini-> Simiiformes-> Catarrhini-> Cercopithecoidea-> Cercopithecidae-> Cercopithecinae
Summary: This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] [NCBI] [Proteinatlas]
Data set information
| Project | Date | Technology | Tissue | Condition | Cell | PMID/DOI |
|---|---|---|---|---|---|---|
| Vthunter_1027 | 2019.11 | 10X Genomics | AorticArtery | Normal | 4383 | Link |
| Vthunter_1028 | 2019.11 | 10X Genomics | CoronaryArtery | Normal | 3606 | Link |
| Vthunter_110069 | 2019.12 | MARS-seq | TotalBrain | Normal | 768 | Link |
Featureplot of receptors
Expression: Biased expression in brain (RPKM 11.8) and gall bladder (RPKM 0.8)
